I ask these yahoos everytime to remove me and they never do.
In fact, some evidence indicates that by answering and asking you just let them verify they have a good number they can now sell to others.  It's the same way with spam email (but email is much worse.)

Thanks for the advice, CrazyBob - I'm gonna do just that the next time this number calls my phone. They call EVERY day!

This number was coming up on my caller ID. They were leaving a message about saving money on prescriptions etc. etc.

I did what I always do...and this is the only hope you will have of stopping the unwanted callers:

I pick up the phone & ask "can you do me a favor please?" (sometimes you will get a response in the affirmative) Then I ask POLITELY, "would you be so kind as to remove me from your calling list?"

I used to curse and slam down the phone. Later, I just ignored the calls. A couple years ago, I realized that both those tactics are completely useless. The verbal method above, combined with registering your phone numbers at "https://www.donotcall.gov/" works 95% of the time.

Non-profit and political calls are exempt from the Do Not Call Registry List, however, I have discovered that if you use the verbal method outlined above, they too will remove you from their calling list.